Conclusion: Our study demonstrates ALDH1 is significantly expressed in dysplatic lesions arising from IBD. ALDH1-expression in cancer stem cells suggest an important causative role in the progression to cancer in IBD. Although we found high sensitivity for dysplasia, the specificity was poor. In addition to neoplasia, ALDH1-expressing stem cells proliferate in response to chronic inflammation, accounting for the cases of inflammatory atypia with positive ALDHI1 expression.
Recommended CitationToll, Adam D.; Boman, Bruce M.; and Palazzo, Juan P., "Expression of Aldehyde Dehydrogenase in Dysplastic Lesions Arising from Inflammatory Bowel Disease" (2011). Department of Pathology, Anatomy and Cell Biology Faculty Papers. Paper 61.