Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.

Authors

Hyowon Choi, Thomas Jefferson UniversityFollow
Zariel I. Johnson, Thomas Jefferson UniversityFollow
Makarand V. Risbud, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

6-1-2015

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Current Stem Cell Research and Therapy

Volume 10, Issue 4, June 2015, Pages 307-316.

The published version is available at DOI: 10.2174/1574888X10666150113112149. Copyright © Bentham Science Publishers

Abstract

Intervertebral disc (IVD) degeneration and associated low back pain (LBP) remains a major burden to our society without significant improvements in treatment strategies or patient's quality of life. While the recent cell-transplantation studies for treatment of degenerative disc disease have shown promising results, to better gauge the success and functional outcomes of these therapies, it is crucial to understand if transplanted cells give rise to healthy nucleus pulposus (NP) tissue. NP cell phenotype is unique and is defined by expression of a characteristic set of markers that reflect specialized physiology and function. This review summarizes phenotypic markers that mirror the unique physiology and function of NP cells and their progenitors and should be considered to when measuring outcomes of cell-based therapies to treat disc degeneration.

Recommended Citation

Choi, Hyowon; Johnson, Zariel I.; and Risbud, Makarand V., "Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration." (2015). Department of Orthopaedic Surgery Faculty Papers. Paper 86.
https://jdc.jefferson.edu/orthofp/86

PubMed ID

25584906