Document Type
Article
Publication Date
8-1-2009
Abstract
Vitamin D deficiency is common in the general public and in patients with cancer. Optimizing vitamin D intake is increasingly recognized in cancer risk reduction, particularly in decreasing colorectal cancer risk. Therefore, summarizing the current evidence to promote best practices related to vitamin D intake and colorectal cancer risk reduction is important. The objectives of this article are to examine the current evidence regarding the impact of vitamin D on colorectal cancer risk reduction and provide practice recommendations for clinicians. Relevant research articles from 2002-2008 were retrieved from multiple electronic databases. Reference lists of relevant articles also were searched manually. Twenty-five research reports were selected for this article: 4 randomized, controlled trials; 11 cohort or case-control studies measuring serum 25-OH-D levels; and 10 cohort studies reporting vitamin D intake. This review generated three themes: raising 25-OH-D levels to a vitamin D sufficient state (32-100 ng/ml) achieved colorectal cancer risk reduction, increasing the intake of vitamin D reduced colorectal cancer risk, and increasing vitamin D intake to 1,000 IU daily is safe and likely sufficient to raise serum 25-OH-D levels above 32 ng/ml to achieve colorectal cancer risk reduction. Several practice recommendations are suggested.
Recommended Citation
Zhou, Guiyun; Stoitzfus, Jill; and Swan, Beth A., "Optimizing vitamin D status to reduce colorectal cancer risk: an evidentiary review." (2009). College of Nursing Faculty Papers & Presentations. Paper 18.
https://jdc.jefferson.edu/nursfp/18
PubMed ID
19648087
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in Clinical Journal of Oncology Nursing Volume 13, Issue 4, August 2009, Pages E3-E17. The published version is available at . DOI: 10.1188/09.CJON.E3-E17. Copyright © Oncology Nursing Society.