Document Type

Letter to the Editor

Publication Date

March 1998

Comments

This letter to the editor was published in the Journal of Neurology, Neurosurgery and Psychiatry 64(3):410-411, March 1998. The published version is available at http://jnnp.bmj.com/cgi/content/full/64/3/410. Copyright (c) 1998 by the BMJ Publishing Group Ltd.

Abstract

Mitochondrial myopathies usually have a chronic course of progressive limb weakness, exercise induced myalgia without muscle tenderness, and normal or only mildly raised serum creatine kinase. Acute or subacute presentation or exacerbation of nervous system signs is common in Leber's hereditary optic neuropathy (LHON) and in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), but has not been reported for muscle in mitochondrial diseases. We describe a patient who presented with rapidly progressive, subacute muscle weakness due to a mitochondrial disorder.

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