Document Type

Article

Publication Date

8-15-2014

Comments

This article has been peer reviewed. It was published in: Journal of Virology.
Volume 88, Issue 16, 2014, Pages 9472-9475.
The published version is available at DOI: 10.1128/JVI.01464-14
Copyright © 2014, American Society for Microbiology

Abstract

We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8(+) T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.

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