Document Type

Article

Publication Date

3-5-2018

Comments

This article has been peer reviewed. It is the author’s final published version in Journal of Experimental and Clinical Cancer Research, Volume 37, Issue 1, March 2018, Article number 43.

The published version is available at https://doi.org/10.1186/s13046-018-0714-6 . Copyright © Zhu et al.

Abstract

BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved.

METHODS: The level of cytosolic Ca

RESULTS: Here, we demonstrated that TNFα induced extracellular Ca

CONCLUSIONS: Our study provides the evidence supporting a novel mechanism by which TNFα induces extracellular Ca

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English

Included in

Oncology Commons

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