Document Type

Article

Publication Date

10-17-2017

Comments

This article has been peer reviewed. It is the author’s final published version in Biomedicines

Volume 5, Issue 4, October 2017, Article number 61.

The published version is available at DOI: 10.3390/biomedicines5040061. Copyright © Rhoades & Gaballa

Abstract

Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understanding of its pathophysiology have come more expansive preclinical and clinical trials, many focused on B cell signaling. This report briefly reviews our current understanding of cGVHD pathophysiology and reviews clinical and preclinical trials with B cell-targeted agents.

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This work is licensed under a Creative Commons Attribution 4.0 License.

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