Copyright (c) 2013 Thomas Jefferson University All rights reserved. http://jdc.jefferson.edu/medgenfp Recent documents in Faculty papers en-us Fri, 22 Feb 2013 17:13:12 PST 3600 http://jdc.jefferson.edu/medgenfp/3 http://jdc.jefferson.edu/medgenfp/3 Fri, 03 Aug 2012 12:32:41 PDT Left ventricular outpouchings are increasingly detected on cardiovascular imaging. Herein, we describe the case of a 45-year-old man who underwent noncardiac preoperative imaging and was found to have an asymptomatic left ventricular outpouching. The patient underwent successful surgical repair of the structure. When left ventricular outpouchings are detected, the main differential diagnoses are pseudoaneurysm, aneurysm, and diverticulum. The outcomes for these conditions differ substantially, and accurate diagnosis can be crucial in making clinical decisions. We review the relevant medical literature, outline the natural history of these left ventricular abnormalities, and discuss options in regard to their management.

]]> Premraj Makkuni et al. Asymptomatic Diseases Cardiac Surgical Procedures Diagnosis, Differential Diverticulum Heart Aneurysm Heart Diseases Heart Ventricles Humans Incidental Findings Male Middle Aged Radionuclide Ventriculography Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Treatment Outcome Ultrasonography, Doppler, Color http://jdc.jefferson.edu/medgenfp/2 http://jdc.jefferson.edu/medgenfp/2 Fri, 03 Aug 2012 12:24:01 PDT Vincent M. Figueredo et al. Aged, 80 and over Amputation Anemia Dyspnea Electrocardiography Female Humans Leg Popliteal Artery Takotsubo Cardiomyopathy Thromboembolism Tibial Arteries http://jdc.jefferson.edu/medgenfp/1 http://jdc.jefferson.edu/medgenfp/1 Tue, 20 Mar 2012 09:15:56 PDT Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been developed for the treatment of atrial fibrillation and atrial flutter. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents, including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine activated potassium current, peak sodium current, and L-type calcium current, and exhibits antiadrenergic effects. It has been studied for maintenance of sinus rhythm and control of ventricular response during episodes of atrial fibrillation. Dronedarone reduces mortality and morbidity in patients with high-risk atrial fibrillation, but may be unsafe in those with severe heart failure. This article will review evidence of safety and effectiveness of dronedarone in patients with atrial fibrillation.

]]> Chinmay Patel et al. Amiodarone Anti-Arrhythmia Agents Atrial Fibrillation Atrial Flutter Humans Ion Channels Kaplan-Meier Estimate