Title
The yin and yang of Fcγ receptors in ITP
Document Type
Article
Publication Date
February 2008
Abstract
The Fcγ receptors contribute to the susceptibility to autoimmune diseases such as ITP in several ways: (1) they modulate dendritic cell antigen processing and presentation, (2) they modulate antibody production by B cells, and (3) they participate in effector cell functions, such as phagocytosis, antibody-dependent cellular cytotoxicity, and mediator release. The key finding in recent years has been the appreciation that the activating Fcγ receptors, encoded by FCGR2A, -2C, -3A, and -3B, compete with the inhibitory Fcγ receptor, encoded by FCGR2B, to determine cellular responses to immune complexes and antibody-coated cells.
Recommended Citation
McKenzie, Steven E., "The yin and yang of Fcγ receptors in ITP" (2008). Department of Medicine Faculty Papers. Paper 32.http://jdc.jefferson.edu/medfp/32
Download
Comments
This article has been peer reviewed. It is the final version as published in Blood 111(3):971-972, February 2008, DOI:10.1182/blood-2007-09-113373. Copyright © 2008 by American Society of Hematology.