Enteric alpha defensins in norm and pathology.

Authors

Nikolai A Lisitsyn, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation
Yulia A Bukurova, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation
Inna G Nikitina, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation
George S Krasnov, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation
Yuri Sykulev, Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson UniversityFollow
Sergey F Beresten, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation

Document Type

Article

Publication Date

1-11-2012

Comments

This article has been peer reviewed and is published in Annals of Clinical Microbiology and Antimicrobials 2012, 11:1. The published version is available at DOI: 10.1186/1476-0711-11-1. ©BioMed Central Ltd.

Abstract

ABSTRACT: Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.

Recommended Citation

Lisitsyn, Nikolai A; Bukurova, Yulia A; Nikitina, Inna G; Krasnov, George S; Sykulev, Yuri; and Beresten, Sergey F, "Enteric alpha defensins in norm and pathology." (2012). Kimmel Cancer Center Faculty Papers. Paper 11.
https://jdc.jefferson.edu/kimmelccfp/11

PubMed ID

22236533