Follow

Submissions from 2013

PDF

Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction., Francesco Addabbo, Qiuying Chen, Dhara P Patel, May Rabadi, Brian Ratliff, Frank Zhang, Jean-Francois Jasmin, Michael Wolin, Michael Lisanti, Steven S Gross, and Michael S Goligorsky

Link

An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development., Bruce M Boman and Jeremy Z Fields

Link

Landscape of the mitochondrial Hsp90 metabolome in tumours., Young Chan Chae, Alessia Angelin, Sofia Lisanti, Andrew V Kossenkov, Kaye D Speicher, Huan Wang, James F Powers, Arthur S Tischler, Karel Pacak, Stephanie Fliedner, Ryan D Michalek, Edward D Karoly, Douglas C Wallace, Lucia R Languino, David W Speicher, and Dario C Altieri

PDF

A phase 1b study of humanized KS-interleukin-2 (huKS-IL2) immunocytokine with cyclophosphamide in patients with EpCAM-positive advanced solid tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, and Roger Stupp

PDF

Circulating tumor DNA to monitor metastatic breast cancer., Massimo Cristofanilli and Paolo Fortina

PDF

Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway., Wei Li, Jing Wang, Qiu-Dan Chen, Xu Qian, Qi Li, Yu Yin, Zhu-Mei Shi, Lin Wang, Jie Lin, Ling-Zhi Liu, and Bing-Hua Jiang

PDF

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4., Ubaldo E. Martinez-Outshoorn, MD; Joseph Curry, MD; Ying-Hui Ko, MD; Zhao Lin, MD; Madalina Tuluc, MD; David Cognetti, MD; Ruth Birbe, MD; Edmund A. Pribitkin, MD; Alessandro Bombonati; Richard Pestell, MD; Anthony Howell; Federica Sotgia; and Michael P. Lisanti, MD

PDF

Caloric restriction augments radiation efficacy in breast cancer., Anthony D Saleh, Brittany A Simone, Juan Palazzo, Jason E Savage, Yuri Sano, Tu Dan, Lianjin Jin, Colin E Champ, Shuping Zhao, Meng Lim, Frederica Sotgia, Kevin Camphausen, Richard G Pestell, James B Mitchell, Michael P Lisanti, and Nicole L Simone

PDF

Peripheral T-cell lymphomas: a review of current approaches and hopes for the future., Alan P Skarbnik, Meher Burki, and Barbara Pro

PDF

Cancer metabolism: new validated targets for drug discovery., Federica Sotgia; Ubaldo E. Martinez-Outshoorn, MD; and Michael P. Lisanti

PDF

The CCL5/CCR5 axis promotes metastasis in basal breast cancer., Marco Velasco-Velázquez and Richard G Pestell

Submissions from 2012

PDF

Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma, Adam C. Berger, Michael Fierro, John C. Kairys, David Berd, Takami Sato, Jocelyn Andrel, Terry Hyslop, and Michael J. Mastrangelo

PDF

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice., Mathew C Casimiro, Marco Crosariol, Emanuele Loro, Adam Ertel, Zuoren Yu, William Dampier, Elizabeth A Saria, Alex Papanikolaou, Timothy J Stanek, Zhiping Li, Chenguang Wang, Paolo Fortina, Sankar Addya, Aydin Tozeren, Erik S Knudsen, Andrew Arnold, and Richard G Pestell

PDF

Genetic Polymorphism in a VEGF-Independent Angiogenesis Gene ANGPT1 and Overall Survival of Colorectal Cancer Patients after Surgical Resection, Jingyao Dai, Shaogui Wan, Feng Zhou, Ronald E. Myers, Xu Guo, Bingshan Li, Xiaoying Fu, Juan P. Palazzo, Kefeng Dou, Hushan Yang, and Jinliang Xing

PDF

Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein., Elisabetta Gazzerro, Simona Baldassari, Caterina Giacomini, Veronica Musante, Floriana Fruscione, Veronica La Padula, Roberta Biancheri, Sonia Scarfì, Valeria Prada, Federica Sotgia, Ian D Duncan, Federico Zara, Hauke B Werner, Michael P Lisanti, Lucilla Nobbio, Anna Corradi, and Carlo Minetti

PDF

The Quest for the Perfect Prostate Biopsy Continues, Leonard G. Gomella

PDF

Enteric alpha defensins in norm and pathology., Nikolai A Lisitsyn, Yulia A Bukurova, Inna G Nikitina, George S Krasnov, Yuri Sykulev, and Sergey F Beresten

PDF

MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1., Zhu-Mei Shi, Jing Wang, Zhiping Yan, Yong-Ping You, Chong-Yong Li, Xu Qian, Yu Yin, Peng Zhao, Ying-Ying Wang, Xie-Feng Wang, Ming-Na Li, Ling-Zhi Liu, Ning Liu, and Bing-Hua Jiang

PDF

Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI., Paul Sirajuddin, Sudeep Das, Lymor Ringer, Olga C Rodriguez, Angiela Sivakumar, Yi-Chien Lee, Aykut Üren, Stanley T Fricke, Brian Rood, Alpay Ozcan, Sean S Wang, Sana Karam, Venkata Yenugonda, Patricia Salinas, Emanuel Petricoin, Michael Pishvaian, Michael P Lisanti, Yue Wang, Richard Schlegel, Bahram Moasser, and Chris Albanese

PDF

Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia., Xiao Wang, Alicia M Pickrell, Teresa A Zimmers, and Carlos T Moraes

PDF

Identification of Functionally Distinct TRAF Proinflammatory and PI3K/MEK Transforming Activities Emanating from the RET/PTC Fusion Oncoprotein, Josephine H.F. Wixted, Jay L. Rothstein, and Laurence C. Eisenlohr

Submissions from 2011

PDF

Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer., Lisa M Arendt, Debra E Rugowski, Tara A Grafwallner-Huseth, Maria Jose Garcia-Barchino, Hallgeir Rui, and Linda A Schuler

PDF

Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells., Matteo Fassan, Domenico D'Arca, Juraj Letko, Andrea Vecchione, Marina P Gardiman, Peter McCue, Bernadette Wildemore, Massimo Rugge, Dolores Shupp-Byrne, Leonard G Gomella, Andrea Morrione, Renato V Iozzo, and Raffaele Baffa

PDF

Regulation of the androgen receptor by SET9-mediated methylation., Luke Gaughan, Jacqueline Stockley, Nan Wang, Stuart R C McCracken, Achim Treumann, Kelly Armstrong, Fadhel Shaheen, Kate Watt, Iain J McEwan, Chenguang Wang, Richard Pestell, and Craig N Robson

PDF

New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer., Abhijit M Godbole and Vincent C O Njar

PDF

A meta-analysis of array-CGH studies implicates antiviral immunity pathways in the development of hepatocellular carcinoma., Xu Guo, Yanna Ba, Xi Ma, Jiaze An, Yukui Shang, Qichao Huang, Hushan Yang, Zhinan Chen, and Jinliang Xing

Link

A tale of three PKCs: epsilon emerges as a driver of pre-neoplastic phenotypes., Karen E Knudsen

PDF

Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor., Eric R Londin, Margaret A Keller, Michael R D'Andrea, Kathleen Delgrosso, Adam Ertel, Saul Surrey, and Paolo Fortina

PDF

Implications of observation-fact modifiers to i2b2 ontologies, Jack W. London and Devjani Chatterjee

Link

Use case and application requirements for a protocol lifecycle tracking tool, with a focus on the trial initiation phase., Jack W. London, Sharon A Elcombe, Alma Villasin, Corey Sagenich, and Paul Davis

Submissions from 2010

PDF

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation., Giovanni L Gravina, Claudio Festuccia, Francesco Marampon, Vladimir M Popov, Richard G Pestell, Bianca M Zani, and Vincenzo Tombolini

PDF

Physiologically based pharmacokinetics of molecular imaging nanoparticles for mRNA detection determined in tumor-bearing mice., Armin W Opitz, Eric Wickstrom, Mathew L Thakur, and Norman J Wagner

PDF

Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma., A Gabriella Wernicke, Adam P Dicker, Michal Whiton, Jana Ivanidze, Terry Hyslop, Elizabeth H Hammond, Arie Perry, David W Andrews, and Lawrence Kenyon

Submissions from 2009

PDF

Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility., Luisa Pecorari, Oriano Marin, Chiara Silvestri, Olivia Candini, Elena Rossi, Clara Guerzoni, Sara Cattelani, Samanta A Mariani, Francesca Corradini, Giovanna Ferrari-Amorotti, Laura Cortesi, Rita Bussolari, Giuseppe Raschellà, Massimo R Federico, and Bruno Calabretta

Submissions from 2008

PDF

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor., Katharine C Degeorge, Brent R Degeorge, James S Testa, and Jay L Rothstein

PDF

Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase., Xuanmao Jiao, Sanjay Katiyar, Manran Liu, Susette C Mueller, Michael P. Lisanti, Anping Li, Timothy G Pestell, Kongming Wu, Xiaoming Ju, Zhiping Li, Erwin F Wagner, Tatsuo Takeya, Chenguang Wang, and Richard G Pestell

PDF

Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection., Michael M Lederman, Robin Jump, Heather A Pilch-Cooper, Michael Root, and Scott F Sieg

PDF

The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis., Jennifer L Marlowe, Yunxia Fan, Xiaoqing Chang, Li Peng, Erik S Knudsen, Ying Xia, and Alvaro Puga

PDF

Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair., Johanna A Smith, Feng-Xiang Wang, Hui Zhang, Kou-Juey Wu, Kevin Jon Williams, and René Daniel

PDF

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation., Zuoren Yu, Chenguang Wang, Min Wang, Zhiping Li, Mathew C Casimiro, Manran Liu, Kongming Wu, James Whittle, Xiaoming Ju, Terry Hyslop, Peter McCue, and Richard G Pestell

Submissions from 2007

PDF

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression., Amy A Baran, Karen A Silverman, Joseph Zeskand, Revati Koratkar, Ashley Palmer, Kristen McCullen, Walter J Curran, Tina Bocker Edmonston, Linda D Siracusa, and Arthur M Buchberg

Submissions from 2006

PDF

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate., Chad D Knights, Jason Catania, Simone Di Giovanni, Selen Muratoglu, Ricardo Perez, Amber Swartzbeck, Andrew A Quong, Xiaojing Zhang, Terry Beerman, Richard Pestell, and Maria Laura Avantaggiati

Submissions from 2004

PDF

ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia., E Canaani, T Nakamura, T Rozovskaia, S T Smith, T Mori, C M Croce, and Alexander Mazo

Link

Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death., Lucia Ricci-Vitiani, Francesca Pedini, Cristiana Mollinari, Gerolama Condorelli, Désirée Bonci, Alessandra Bez, Augusto Colombo, Eugenio Parati, Cesare Peschle, and Ruggero De Maria

Submissions from 2001

Link

The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro., A E Engqvist-Goldstein, R A Warren, M M Kessels, James H Keen, J Heuser, and D G Drubin

Submissions from 2000

PDF

A cultivated taste for yeast., C Brenner