Rabkin, et al. describes a 4% incidence of phenelzine-induced edema, which appears to be due to increased capillary permeability (1,2). This adverse effect is not further characterized in the literature and is not readily mentioned as one of the many drug effects that could result in severe physical morbidity. We present the case of a depressed patient who developed a generalized edema severe enough to deserve an extensive medical workup. Once the drug was tapered, the edema and its associated symptoms rapidly resolved.
Bobo, William M.D. and Hemme, Cheryl A. M.D.
"Severe Generalized Edema Associated with Phenelzine,"
Jefferson Journal of Psychiatry:
1, Article 7.
Available at: http://jdc.jefferson.edu/jeffjpsychiatry/vol16/iss1/7