Copyright (c) 2013 Thomas Jefferson University All rights reserved. http://jdc.jefferson.edu/headache Recent documents in Department of Jefferson Headache Center papers and presentations en-us Sat, 06 Apr 2013 01:39:51 PDT 3600 http://jdc.jefferson.edu/headache/3 http://jdc.jefferson.edu/headache/3 Thu, 04 Apr 2013 08:24:05 PDT Recent trials have demonstrated that onabotulinumtoxinA is a safe and effective treatment for the prevention of chronic migraine headaches. Although the exact effect of the toxin on the pathophysiology of migraine is not clear, several in-vivo and in-vitro models have shown that onabotulinumtoxinA inhibits the release of neurotransmitters and neuropeptides involved in pain signaling pathways with resulting attenuation of both peripheral and central sensitization in migraine. Limited systemic adverse effects and physician administered treatments that eliminate concerns for patient compliance have made onabotulinumtoxin A an appealing alternative to oral prophylactic medications for migraine. This article is designed to provide an overview of current research into the mechanism of action of onabotulinumtoxinA in the pathophysiology of pain conditions including migraine, as well the current literature supporting its efficacy in migraine treatment.

]]> Carrie O. Dougherty, MD et al. http://jdc.jefferson.edu/headache/2 http://jdc.jefferson.edu/headache/2 Fri, 11 Sep 2009 07:53:06 PDT To examine frovatriptan's efficacy as preemptive treatment for fasting-induced migraine.

]]> Meryl Latsko, MD, MPH et al. http://jdc.jefferson.edu/headache/1 http://jdc.jefferson.edu/headache/1 Fri, 11 Sep 2009 07:48:40 PDT To examine the use of DHE NS (Migranal®) in the early and late treatment of migraine in subjects with a history of cutaneous allodynia.

]]> Meryl Latsko, MD, MPH et al.