Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery.

Authors

Ipsita Mohanty, Thomas Jefferson UniversityFollow
Subas Chandra Parija, Orissa University of Agriculture and Technology
Sujit Suklabaidya, Institute of Life Sciences, Bhubaneswar, Odisha, India
Satish Rattan, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

3-7-2018

Comments

This article has been peer reviewed. It is the author’s final published version in European Journal of Pharmacology, Volume 827, March 2018, Pages 22-31.

The published version is available at https://doi.org/10.1016/j.ejphar.2018.03.004 . Copyright © Elsevier

Abstract

Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions. We investigated the unknown effects of extracellular acidosis on relaxation in the superior mesenteric artery (SMA) of goat. SMA rings were employed to maintain isometric contractions at extracellular pH (pH

Recommended Citation

Mohanty, Ipsita; Parija, Subas Chandra; Suklabaidya, Sujit; and Rattan, Satish, "Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery." (2018). Division of Gastroenterology and Hepatology Faculty Papers. Paper 49.
https://jdc.jefferson.edu/gastro_hepfp/49

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

29524386

Language

English