Document Type
Article
Publication Date
8-30-2024
Abstract
Neuropsychiatric symptoms (including anxiety, depression, apathy, impulse–compulsive behaviors and hallucinations) are among the most common non-motor features of Parkinson’s disease. Whether these symptoms should be considered as a direct consequence of the pathophysiologic mechanisms of Parkinson’s disease is controversial. Morphometric similarity network analysis and epicenter mapping approach were performed on T1-weighted images of 505 patients with Parkinson’s disease and 167 age- and sex-matched healthy participants from Parkinson’s Progression Markers Initiative database to reveal the commonalities and specificities of distinct neuropsychiatric symptoms. Abnormal cortical co-alteration pattern in patients with neuropsychiatric symptoms was in somatomotor, vision and frontoparietal regions, with epicenters in somatomotor regions. Apathy, impulse–compulsive behaviors and hallucinations shares structural abnormalities in somatomotor and vision regions, with epicenters in somatomotor regions. In contrast, the cortical abnormalities and epicenters of anxiety and depression were prominent in the default mode network regions. By embedding each symptom within their co-alteration space, we observed a cluster composed of apathy, impulse–compulsive behaviors and hallucinations, while anxiety and depression remained separate. Our findings indicate different structural mechanisms underlie the occurrence and progression of different neuropsychiatric symptoms. Based upon these results, we propose that apathy, impulse-compulsive behaviors and hallucinations are directly related to damage of motor circuit, while anxiety and depression may be the combination effects of primary pathophysiology of Parkinson’s disease and psychosocial causes.
Recommended Citation
Lu, Qianling; Zhu, Zhuang; Zhang, Heng; Gan, Caiting; Shan, Aidi; Gao, Mengxi; Sun, Huimin; Cao, Xingyue; Yuan, Yongsheng; Tracy, Joseph I; Zhang, Qirui; and Zhang, Kezhong, "Shared and Distinct Cortical Morphometric Alterations in Five Neuropsychiatric Symptoms of Parkinson’s Disease" (2024). Farber Institute for Neuroscience Faculty Papers. Paper 64.
https://jdc.jefferson.edu/farberneursofp/64
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
39214962
Language
English
Comments
This article is the author's final published version in XYZ, Volume X, Issue Y, Month Year, Article number Z.
The published version is available at https://doi.org/10.1038/s41398-024-03070-z.
Copyright © 2024 The Authors.