We have demonstrated that priming of intratumoral and intradermal vaccination sites with chemokines enhances cytotoxic immune response against established neoplasms. Additional insights into the molecular mechanisms that underlie these findings and the optimization of such an approach may lead to the development of cost-effective and generic immunotherapeutic regimens against cancer.
Recommended CitationIgoucheva, Olga; Jonas, Rebecca; and Alexeev, Vitali, "Chemokine-enhanced DNA vaccination in cancer immunotherapy." (2013). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 32.