Document Type

Article

Publication Date

11-1-2013

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Clinics in Dermatology.

Volume 31, Issue 6, November-December 2013, Pages 787-91.

The published version is available at DOI: 10.1016/j.clin dermatol.2013.05.018. Copyright © Elsevier Inc.

Abstract

There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.

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