Document Type

Article

Publication Date

August 2006

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Proceedings of the National Academy of Sciences of the United States of America 103(31): 11567-11572, August 2006. The published version is available at http://dx.doi.org/10.1073/pnas.0603363103, copyright © 2006 by The National Academy of Sciences of the USA.

Abstract

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in expression and activity by cyclin D1. Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function.