Purpose: Radiation therapy (RT) is delivered after radical prostatectomy (RP) for prostate cancer (PC). Although intensity modulated radiation therapy (IMRT) has become standard in definitive RT for PC, dosimetric data in support of post-RP IMRT are limited. This study was designed to quantify benefits of IMRT versus 3D conformal RT (3DCRT) with respect to dose sparing of rectum and bladder and target volume coverage. Motivated by the desire to deliver higher radiation doses and to quantify the dosimetric impact of IMRT, we retrospectively analyzed images in order to: 1) identify a preferred IMRT beam arrangement; 2) evaluate the dosimetric advantages of IMRT compared to 3DCRT; and 3) assess the variation of dosimetric parameters during the RT course using conebeam CT (CBCT) images.
American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA
Studenski, M.; Harrison, A.; Anamalayil, S.; Harvey, A.; Trabulsi, E.; Xiao, Y.; Yu, Y.; Dicker, A. P.; and Showalter, T. N.
"Potential for Dose-escalation in the Post-prostatectomy Setting with Intensitymodulated Radiation Therapy: A Dosimetric Study Using EORTC Consensus Guidelines for Target Volume Contours,"
1, Article 42.
Available at: http://jdc.jefferson.edu/bodinejournal/vol3/iss1/42