Bodine Journal Copyright (c) 2013 Thomas Jefferson University All rights reserved. http://jdc.jefferson.edu/bodinejournal Recent documents in Bodine Journal en-us Fri, 22 Feb 2013 16:36:04 PST 3600 Jefferson Kimmel Cancer Center Support Groups http://jdc.jefferson.edu/bodinejournal/vol3/iss1/49 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/49 Wed, 01 Dec 2010 12:40:41 PST Listing of Jefferson Kimmel Cancer Center Support Groups.

]]> Research Department of Radiation Oncology http://jdc.jefferson.edu/bodinejournal/vol3/iss1/48 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/48 Wed, 01 Dec 2010 12:40:40 PST Listing of Basic Research Studies/Grants and Clinical Research Studies/Grants.

]]> Young Investigator Awards http://jdc.jefferson.edu/bodinejournal/vol3/iss1/47 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/47 Wed, 01 Dec 2010 12:39:05 PST Robert Den, MD, Laura Doyle, MS, Nitin Ohri, MD and Evan Wuthrick, MD

]]> New Faculty Members http://jdc.jefferson.edu/bodinejournal/vol3/iss1/46 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/46 Wed, 01 Dec 2010 12:39:05 PST New faculty members: Voichita (Voika) Bar Ad, MD and Wenyin Shi, MD, PhD.

]]> Departmental Information-Thomas Jefferson University, Jefferson Medical College, Department of Radiation Oncology http://jdc.jefferson.edu/bodinejournal/vol3/iss1/45 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/45 Wed, 01 Dec 2010 12:39:04 PST Directory of Attending Physicians, Division of Molecular Radiology, Division of Medical Physics, Radiation Oncology Residents, Medical Physics Residents/Research Staff and Administration.

]]> The GUCY2C Tumor Suppressor is the Nexus of a Paracrine Hormone Axis Preventing Radiotherapy-Induced Gastrointestinal (GI) Toxicity http://jdc.jefferson.edu/bodinejournal/vol3/iss1/44 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/44 Wed, 01 Dec 2010 12:39:03 PST Purpose/Objective: Radiation-induced GI toxicity is the primary dose limitation compromising therapy in cancer patients treated with radiation therapy. GUCY2C is the intestinal receptor for diarrheagenic bacterial enterotoxins and the endogenous paracrine hormones guanylin and uroguanylin. Following genomic insult, cyclic (c)GMP produced by ligand activation of GUCY2C enhances DNA damage sensing and repair in intestinal cells. Here, we show that the GUCY2C-cGMP axis mediates p53-dependent radioprotection of intestinal epithelial cells.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> E. J. Wuthrick et al. Chart Rounds in the Digital Age: A Survey of North American Institutions http://jdc.jefferson.edu/bodinejournal/vol3/iss1/43 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/43 Wed, 01 Dec 2010 12:39:02 PST Purpose/Objective(s): In light of public concerns regarding the quality of radiation treatment delivery, we surveyed the utilization of “chart rounds” or peer-review quality assurance meetings, within North American academic institutions.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> M. A. Whiton et al. Potential for Dose-escalation in the Post-prostatectomy Setting with Intensitymodulated Radiation Therapy: A Dosimetric Study Using EORTC Consensus Guidelines for Target Volume Contours http://jdc.jefferson.edu/bodinejournal/vol3/iss1/42 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/42 Wed, 01 Dec 2010 12:39:01 PST Purpose: Radiation therapy (RT) is delivered after radical prostatectomy (RP) for prostate cancer (PC). Although intensity modulated radiation therapy (IMRT) has become standard in definitive RT for PC, dosimetric data in support of post-RP IMRT are limited. This study was designed to quantify benefits of IMRT versus 3D conformal RT (3DCRT) with respect to dose sparing of rectum and bladder and target volume coverage. Motivated by the desire to deliver higher radiation doses and to quantify the dosimetric impact of IMRT, we retrospectively analyzed images in order to: 1) identify a preferred IMRT beam arrangement; 2) evaluate the dosimetric advantages of IMRT compared to 3DCRT; and 3) assess the variation of dosimetric parameters during the RT course using conebeam CT (CBCT) images.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> M. Studenski et al. Costs of Early Adjuvant Radiation Therapy After Radical Prostatectomy: A Decision Analysis http://jdc.jefferson.edu/bodinejournal/vol3/iss1/41 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/41 Wed, 01 Dec 2010 12:37:27 PST Purpose/Objective(s): Prospective, randomized trials support adjuvant radiation therapy (RT) for adverse pathologic features after radical prostatectomy (RP). However, adjuvant RT is not universally delivered in this setting. Criticisms of adjuvant RT include toxicity, financial costs, potential overtreatment, and effectiveness of salvage RT. The objective of this study was to construct a decision analytic model to estimate real world cost of RT vs. no RT within the context of the effectiveness of early adjuvant RT for prostate patients based on published clinical results of the Southwest Oncology Group prospective trial of adjuvant RT (SWOG 8794).

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> T. N. Showalter et al. Intensity Modulated Radiation Therapy Compared with 3D Conformal Radiotherapy for Craniospinal Irradiation in Adults – Do We Gain Anything? http://jdc.jefferson.edu/bodinejournal/vol3/iss1/40 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/40 Wed, 01 Dec 2010 12:37:27 PST Purpose: Craniospinal irradiation (CSI) remains one of the most technically challenging planning processes in radiation oncology due to its long shape especially in adults and complex target volume. In addition, CSI is associated with significant acute and late morbidities. We undertook a dosimetric analysis to determine if intensity modulated radiation therapy (IMRT) could improve target coverage while sparing normal tissue structures compared to classic 3D conformal radiation (3D‐CRT) planning.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> X. Shen et al. MIRAB: An Image-Guided Multichannel Robot for Prostate Brachytherapy http://jdc.jefferson.edu/bodinejournal/vol3/iss1/39 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/39 Wed, 01 Dec 2010 12:37:26 PST Purpose: To date, twelve robotic systems have been developed worldwide for brachytherapy, especially for seed implantation. However, the only system that has provision for simultaneous insertion of multiple needles is the MIRAB system. This article reports the feasibility and efficacy of the MIRAB robot as ultrasound image-guided autonomous delivery of radioactive seeds for treating prostate cancers.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> T. Podder et al. Reirradiation for Recurrent Meningioma http://jdc.jefferson.edu/bodinejournal/vol3/iss1/38 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/38 Wed, 01 Dec 2010 12:37:26 PST Purpose/Objective(s): Management options for meningioma include observation, surgical resection, and radiation therapy (RT). In cases of progressive or recurrent disease after RT, similar options exist. The control rate following a second course of RT is unknown.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> N. Ohri et al. Prophylactic Radiation Therapy is Safe and Effective Treatment for the Prevention of Recurrent Heterotopic Ossification in Elbow and Knee Joints http://jdc.jefferson.edu/bodinejournal/vol3/iss1/37 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/37 Wed, 01 Dec 2010 12:37:25 PST Background: Background Prophylactic radiation therapy (RT) is an established adjuvant therapy for heterotopic ossification (HO) of the hip when delivered in the immediate pre- or post-operative setting. Its role in prevention of recurrence after excision of HO is supported by randomized trials for HO of the hip, but there is scant evidence to support a similar approach in non-hip joints. In the current study, we evaluate radiologic and functional outcomes after prophylactic radiation therapy (RT) for prevention of HO of the knee and upper extremity [elbow and metacarpophalangeal (MCP) joints].

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> M. V. Mishra et al. Evolving Role of Vorinostat Combined with Radiation Therapy in the Treatment of Brain Tumors, from the Lab to the Clinic http://jdc.jefferson.edu/bodinejournal/vol3/iss1/36 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/36 Wed, 01 Dec 2010 12:37:24 PST Purpose/Objective(s): Radiation therapy (RT) is a critical element in the treatment of both brain metastases and glioblastoma (GBM). Temozolomide (TMZ) has an established role in the upfront treatment of GBM. Down-regulated mismatch repair (MMR) is a known mechanism of resistance to TMZ. Vorinostat (SAHA), an HDAC inhibitor, has successfully been combined with a number of cytotoxic agents, including ionizing radiation (IR). We performed a series of preclinical and clinical studies to examine the role of SAHA in the treatment of brain tumors.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> Y. R. Lawrence et al. Early Stage Testicular Seminoma: A Multicenter Review of Treatment Outcomes and Patterns of Recurrence http://jdc.jefferson.edu/bodinejournal/vol3/iss1/35 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/35 Wed, 01 Dec 2010 12:35:54 PST Purpose/Objective(s): Although overall survival for early stage testicular seminoma is generally excellent, certain pathologic factors can increase recurrence risk for those undergoing observation, while radiation therapy (RT) can be associated with long-term morbidity. We sought to identify disease-related and treatment-related factors that influenced the outcomes, with particular emphasis on recurrence risk, patterns and timing of recurrence, as well as RT-induced malignancy.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> M. Kim et al. Substantial Dose-response Relationship with Clinical Outcome for Lung Stereotactic Body Radiotherapy (SBRT) Delivered via Online Image Guidance http://jdc.jefferson.edu/bodinejournal/vol3/iss1/34 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/34 Wed, 01 Dec 2010 12:35:53 PST Purpose: To examine potential tumor dose-response relationships with various non-small cell lung cancer (NSCLC) SBRT fractionation regimens delivered with online CT-based image guidance.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> L. Kestin et al. Poor Pulmonary Function is Not Associated with Increased Rates of Toxicity or Decreased Overall Survival After Stereotactic Body Radiotherapy for Early Stage Non-Small Cell Lung Cancer: Results of a Multi-institutional Analysis http://jdc.jefferson.edu/bodinejournal/vol3/iss1/33 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/33 Wed, 01 Dec 2010 12:35:52 PST Purpose/Objective(s): Stereotactic body radiotherapy (SBRT) is considered as the treatment of choice for stage I non-small cell lung cancer (NSCLC) in medically inoperable patients. It was the purpose of this study to evaluate whether pretreatment pulmonary function is predictive for survival and toxicity after SBRT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> M. Guckenberger et al. A Multi-national Pooled Analysis of 434 Cases of Stage I Non-small Cell Lung Cancer (NSCLC) Treated with Volumetrically Image-guided Stereotactic Lung Radiotherapy: Results from the Elekta Collaborative Lung Research Group http://jdc.jefferson.edu/bodinejournal/vol3/iss1/32 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/32 Wed, 01 Dec 2010 12:34:54 PST Background: Published lung SBRT outcomes/dose response data for inoperable NSCLC come from small phase I-II studies or larger datasets not requiring image-guided radiotherapy (IGRT) or volumetric prescriptions. This entire cohort of SBRT patients had daily online cone-beam CT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> I. S. Grills et al. Toxicity of Phase I Radiation Oncology Trials: Worldwide Experience http://jdc.jefferson.edu/bodinejournal/vol3/iss1/31 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/31 Wed, 01 Dec 2010 12:34:54 PST Introduction: Informed consent involves understanding the risks and benefits of trial enrollment. This is challenging in the phase I setting since true quantitative information is never known. We therefore performed an analysis of published radiation oncology (RO) phase I trials emphasizing patient outcomes. To our knowledge, no such systemic analysis has previously been published.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> C. Glass et al. Pathologic Correlation of PET-CT Based Auto Contouring for Radiation Planning in Lung Cancer http://jdc.jefferson.edu/bodinejournal/vol3/iss1/30 http://jdc.jefferson.edu/bodinejournal/vol3/iss1/30 Wed, 01 Dec 2010 12:34:53 PST Purpose/Objective(s): Radiation therapy in lung cancer relies on CT and functional imaging (FDG-PET) to delineate tumor volumes. Semi-automatic contouring tools have been developed for PET to improve on the inter-observer bias of manual contouring and intrinsic differences in imaging equipment. A common method involves using a threshold at a given percentage of the max activity, which may be less accurate with smaller tumors and tumors with low source to background ratio. To overcome this deficiency, a gradient algorithm, which detects changes in image counts at the border of the tumor, has been developed. Few studies have correlated these methods to pathological specimens.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

]]> S. E. Fogh et al.