Document Type


Publication Date

March 2006


This article has been peer-reviewed. It is the authors' final version prior to publication in Trends in Biochemical Sciences 31(3):143-149, March, 2006. The published version is available at Copyright is retained by Elsevier, Inc.


Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how this essential step of translation occurs. However, there remains ongoing controversy regarding the other actions of RRF and EF-G during ribosome recycling. We propose that the available data are consistent with the notion that RRF and EF-G not only split ribosomes into subunits but also participate directly in the release of deacylated tRNA and mRNA for the next round of translation.



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