In this issue a very significant contribution to cardiology describing critical roles of ATE1 appears by Kurosaka et al. . In view of this paper, as the discoverers of ATE1, we have been asked to contribute an article (editorial) regarding ATE1 (enzyme which transfers arginine from arginyl tRNA to protein acceptors). This short article consists of three sections: 1) a historical anecdote describing how ATE1 was discovered; 2) its possible role in aging and cellular transformation, and most importantly; 3) its role in the development and maintenance of cardiac activity. The last section has direct bearing to the Kurosaka et al. paper.
Recommended CitationKaji, Hideko and Kaji, Akira, "Global cellular regulation including cardiac function by post-translational protein arginylation." (2012). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 41.