Document Type

Article

Publication Date

8-1-2015

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in DNA Repair

Volume 32, August 2015, Pages 10-16.

The published version is available at DOI: 10.1016/j.dnarep.2015.04.008. Copyright © Elsevier

Abstract

Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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